Immune-related cardiotoxicities predict immune checkpoint inhibitors treatment for advanced non-small cell lung cancer: a retrospective multi-center study
Mild irAEs or immune-related cardiotoxicities (grade 1-2) did not extend median OS in NSCLC patients. The prognostic model incorporating PLR, CEA, and CYFRA21-1 could contribute to predicting the treatment efficacy and prognosis of ICI treatment.
Authors
- Yukun Wang (ORCID: https://orcid.org/0000-0003-4521-2309)
- Caicun Zhou (ORCID: https://orcid.org/0000-0002-1072-9941)
- Yini Huang (ORCID: https://orcid.org/0000-0002-4890-9665)
- Hao Tang (ORCID: https://orcid.org/0000-0003-0849-1302)
- Siwan Wen (ORCID: https://orcid.org/0000-0001-7000-2886)
- Yanbin Kuang (ORCID: https://orcid.org/0000-0003-3041-7854)
- Junyong Zou (ORCID: https://orcid.org/0000-0001-5307-2647)
- Hui Sun (ORCID: https://orcid.org/0000-0003-4928-9450)
- Yang Chen (ORCID: https://orcid.org/0000-0003-4749-3060)
- Xiaoming Li (ORCID: https://orcid.org/0000-0003-1795-0371)
- Fenyong Sun
- Changhui Wang (ORCID: https://orcid.org/0000-0002-7583-6545)
- Hongxia Duan (ORCID: https://orcid.org/0000-0001-7925-8925)
- Feng Hu (ORCID: https://orcid.org/0000-0002-6589-3861)
- Dachun Xu (ORCID: https://orcid.org/0000-0002-9821-7368)
- Yingyi Qin
- Fengming Ding
- Mengting Xiong
- Shuanshuan Xie
Institutions
- Tongji University (CN)
- Second Military Medical University (CN)
- Shanghai Jiao Tong University (CN)
- Shanghai Chest Hospital (CN)
- Tongren Hospital (CN)
- Shanghai Pulmonary Hospital (CN)
- Shanghai East Hospital (CN)
- Shanghai Tenth People's Hospital (CN)
- Shanghai First People's Hospital (CN)
- Tongji Hospital (CN)
Publication Details
- Journal
- Journal of Thoracic Disease
- Published
- 2025-09-01
- DOI
- https://doi.org/10.21037/jtd-2025-374
- Primary Topic
- Cancer Immunotherapy and Biomarkers
- Type
- article
- Field-Weighted Citation Impact
- 0.00