A case of Kawasaki disease refractory to initial intravenous immunoglobulin therapy linked to febrile seizures at Japanese Red Cross Maebashi Hospital, Japan

Febrile seizures (FS) and Kawasaki disease (KD) are both common pediatric conditions among the Asian population. However, FS rarely occur during KD, and the relationship between the two is unclear. Herein, we report the case of a 17-month-old boy of KD with FS. Despite low predictive risk scores for initial intravenous immunoglobulin (IVIG) therapy failure, none of which include seizures as a risk factor, initial IVIG failed to provide symptom relief, necessitating a second IVIG and intravenous prednisolone. In KD, FS may themselves contribute to IVIG resistance.