SALL4 Is Required for YAP1-Dependent Malignant and Regenerative Hepatocyte-to-Cholangiocyte Reprogramming
HC plasticity supports repair but can drive malignancy, acting as a double-edged sword. We identify SALL4 as regulator of YAP1-driven HC-to-CC reprogramming, revealing the YAP1-SALL4-BMI1 axis as a therapeutic target for CCA.
Authors
- Sungjin Ko (ORCID: https://orcid.org/0000-0002-6079-5939)
- Silvia Liu (ORCID: https://orcid.org/0000-0002-1840-9520)
- Yoojeong Park (ORCID: https://orcid.org/0009-0005-1828-7147)
- Minwook Kim (ORCID: https://orcid.org/0000-0002-0093-4562)
- Rachel Covitz (ORCID: https://orcid.org/0009-0003-7296-9830)
- Joseph Kwon (ORCID: https://orcid.org/0009-0005-9945-2211)
- Jiajun Liu (ORCID: https://orcid.org/0009-0001-3677-613X)
Institutions
- University of Pittsburgh (US)
- University of Pittsburgh Medical Center (US)
Publication Details
- Journal
- Cancer Research Communications
- Published
- 2025-09-01
- DOI
- https://doi.org/10.1158/2767-9764.crc-25-0172
- Citations
- 1
- Primary Topic
- Liver physiology and pathology
- Type
- article
- Field-Weighted Citation Impact
- 1.32