Effect of Fospropofol Disodium on Perioperative Neurocognitive Function in Elderly Patients Undergoing Total Hip Arthroplasty
Fospropofol disodium may be a viable alternative in settings where injection pain and PONV are primary concerns, provided that hemodynamic stability is actively managed in elderly THA patients, with non-inferior efficacy in preventing PND compared to propofol and fewer adverse effects. Age and preoperative cognitive function are critical predictors of PND, warranting careful consideration in perioperative management.
Authors
- Li Xie (ORCID: https://orcid.org/0000-0001-7250-4054)
- Hongrui Zhu (ORCID: https://orcid.org/0000-0001-6823-6827)
- Jiawei Xiao (ORCID: https://orcid.org/0000-0002-8145-9846)
- Sheng Wang (ORCID: https://orcid.org/0000-0003-0723-8495)
- Sheng Ding (ORCID: https://orcid.org/0000-0002-1612-3342)
- Chunliu Li
- Zaibao Wang (ORCID: https://orcid.org/0009-0009-5311-8559)
- Keqiang He (ORCID: https://orcid.org/0000-0002-2750-5055)
- Weidong Zhang (ORCID: https://orcid.org/0000-0002-7384-2490)
- Min Xu (ORCID: https://orcid.org/0009-0004-5202-9785)
- Yan Meng (ORCID: https://orcid.org/0000-0002-0567-5205)
- Chen Gao (ORCID: https://orcid.org/0000-0002-2860-4784)
Institutions
- Wannan Medical College (CN)
- University of Science and Technology of China (CN)
- Bengbu Medical College (CN)
Publication Details
- Journal
- Drug Design Development and Therapy
- Published
- 2025-09-01
- DOI
- https://doi.org/10.2147/dddt.s548597
- Primary Topic
- Intensive Care Unit Cognitive Disorders
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Natural Science Foundation of China
- University of Science and Technology of China