Regression of Hypertrophic Scars in Herpes Zoster Using Umbilical Cord Mesenchymal Stem Cells and Plant-Derived Exosomes: A Case Report

Herpes zoster (HZ), caused by the reactivation of latent varicella-zoster virus (VZV) in sensory ganglia, manifests as a painful, unilateral vesicular rash along dermatomal distributions [1].While antiviral therapies and analgesics mitigate acute symptoms, postherpetic complications such as scarring remain a significant burden.Approximately 10-20% of HZ patients develop hypertrophic or atrophic scars, characterized by dyspigmentation, fibrosis, and impaired skin integrity, which persist despite conventional interventions [2].These scars contribute to long-term physical discomfort, psychosocial distress, and reduced quality of life, underscoring the need for innovative therapeutic strategies [1].