The Influence of the Combined Use of Various Forms of Preparations Containing Oxidized Dextran on the Reproductive Status of Men with Idiopathic and Secondary Infertility

Introduction:The study of fertility is of great scientific interest due to the impact of numerous external factors on the body, which significantly affect male reproductive status.The assessment of changes in spermograms is necessary for the diagnosis, treatment, and prognosis of recovery in various forms of infertility.The results of this study are based on the dynamic examination of ejaculate parameters using the active substance -oxidized dextran, in the form of capsules for oral use and rectal suppositories.The Aim of the Study: to evaluate the effectiveness of using a combination of rectal and oral forms of oxidized dextran in the treatment of men with idiopathic and secondary infertility. Materials and Methods.At the base of LLC "RMDC Clinic," 37 patients aged 18 to 55 were examined, of whom 65% were found to have idiopathic infertility, while the rest had secondary infertility as a complication of the latent course of chronic nonspecific prostatitis.The evaluation of the main clinical and laboratory indicators was conducted: assessment of the basic spermogram, MAR-test with determination of IgA and IgG fractions (%) and the sperm DNA fragmentation index (SDFI).All patients were offered a new method for correcting pathospermia with a total duration of 4 months, during which for the first month, men received oxidized dextran in the form of rectal suppositories "ANDROEXPERT SV1" (active ingredient content, oxidized dextran -100 mg per suppository) every night.In the following 3 months, the intake of rectal suppositories continued in the same dosage with a frequency of "every other day"; additionally, patients received the same medication in the form of capsules (active ingredient content, oxidized dextran -0.25 mg per capsule) twice daily. Results:The concentration of spermatozoa by the end of the treatment course increased compared to the baseline values by 73.1% (p < 0.001), the total number of spermatozoa in the ejaculate increased by 63.6% (p < 0.001); the fraction of progressively motile spermatozoa ("A" + "B") increased by 90.5% (p < 0.001) due to the "A" fraction, which increased tenfold (p < 0.025), which affected the increase in total sperm motility ("A" + "B" + "C") by 28.9% (p < 0.001), the fraction of immotile spermatozoa ("D") decreased by 23.6% (p < 0.001).The sperm viability rate increased by 20% (p < 0.001).A positive trend was observed in the MAR-test indicators,