Immunological microenvironment differences between left and right colon cancer: dynamic interactions of CASC15+KLK6+ epithelial subpopulation with T cells and mast cells
RCC harbors an immunosuppressive niche driven by T-cell exhaustion, MC reprogramming, and expansion of a malignant CASC15 + KLK6 + epithelial subpopulation. Targeting MIF and CD99 signaling networks represents a potential therapeutic strategy for RCC.
Authors
- Feng Gao (ORCID: https://orcid.org/0000-0002-6647-5522)
- Le Yang (ORCID: https://orcid.org/0000-0002-5745-0972)
- Yuxiang Zhao (ORCID: https://orcid.org/0000-0003-4624-4388)
- Wei Cui (ORCID: https://orcid.org/0000-0001-7281-3471)
- Yu Wang
- Hao Liu (ORCID: https://orcid.org/0000-0001-6338-4003)
- Yibin Zhao (ORCID: https://orcid.org/0000-0001-5031-7725)
- Peiyuan Li (ORCID: https://orcid.org/0000-0002-1463-5985)
- Jie Shen (ORCID: https://orcid.org/0009-0000-1484-6523)
Institutions
- Sun Yat-sen University (CN)
- Sixth Affiliated Hospital of Sun Yat-sen University (CN)
- Ningbo Medical Center Lihuili Hospital (CN)
- Bioengineering Center (RU)
- Bio-Medical Science (South Korea) (KR)
Publication Details
- Journal
- International Journal of Surgery
- Published
- 2025-09-09
- DOI
- https://doi.org/10.1097/js9.0000000000003453
- Citations
- 1
- Primary Topic
- Macrophage Migration Inhibitory Factor
- Type
- article
- Field-Weighted Citation Impact
- 0.80