Single-cell transcriptome analysis reveals regulatory programs associated with tumor resistance during immunotherapy in colorectal cancer
This study highlights the pivotal role of T-cell subsets in patients with metastatic dMMR CRC who resistant to anti-PD-1 therapy, revealing that transcriptional dysregulation and impaired cell communication networks are central mechanisms underlying drug resistance. Notably, KLRB1 has been identified as a promising biomarker for immunotherapy response in CRC patients.
Authors
- Dali Xi
- Lei Jiang (ORCID: https://orcid.org/0000-0002-9479-132X)
- Yan Chen (ORCID: https://orcid.org/0000-0003-1017-4007)
- Cong Wang (ORCID: https://orcid.org/0000-0001-8550-9823)
- Tao Liu (ORCID: https://orcid.org/0000-0001-8299-646X)
- Guangtao Min
Institutions
- Wuhan Institute of Bioengineering (CN)
- First Hospital of Lanzhou University (CN)
- Lanzhou University (CN)
Publication Details
- Journal
- International Journal of Surgery
- Published
- 2025-09-09
- DOI
- https://doi.org/10.1097/js9.0000000000003459
- Citations
- 2
- Primary Topic
- Cancer Immunotherapy and Biomarkers
- Type
- article
- Field-Weighted Citation Impact
- 2.09