Tirzepatide retention in iWAT with mesoporous polydopamine encapsulation enhances weight loss through leptin receptor signaling
These findings indicate that the retention of TZP in iWAT via MPDA encapsulation amplified its effect on weight loss in mice through leptin receptor signaling compared with TZP alone, which provides new insights into the tissue-specific mechanism and alternative delivery strategies of TZP for targeting specific WAT tissues.
Authors
- Zecong Xiao (ORCID: https://orcid.org/0000-0002-7923-5309)
- Guojun Shi (ORCID: https://orcid.org/0000-0002-3098-6662)
- Xintao Shuai (ORCID: https://orcid.org/0000-0003-4271-0310)
- Jiahai Wang (ORCID: https://orcid.org/0000-0002-4846-7561)
- Xiaoxin Xiang (ORCID: https://orcid.org/0000-0002-6908-9889)
- Sijia Shang
- Shumeng Chen
- Yanyu Chen (ORCID: https://orcid.org/0000-0002-5534-0083)
- Jiaoting Chen
- Lin Mi (ORCID: https://orcid.org/0000-0002-9592-020X)
- Yanming Chen (ORCID: https://orcid.org/0000-0001-6255-0938)
- Jun Peng (ORCID: https://orcid.org/0000-0003-0271-7956)
- Tan Li
- Na Xiong
- Wai W. Cheung
- Yawen Zhou (ORCID: https://orcid.org/0009-0009-7191-0187)
Institutions
- Sun Yat-sen University (CN)
- University of California San Diego (US)
- Guangzhou University (CN)
- Second Affiliated Hospital of Guangzhou Medical University (CN)
- Sixth Affiliated Hospital of Sun Yat-sen University (CN)
- Third Affiliated Hospital of Sun Yat-sen University (CN)
- Guangzhou Medical University (CN)
Publication Details
- Journal
- Journal of Advanced Research
- Published
- 2025-09-01
- DOI
- https://doi.org/10.1016/j.jare.2025.09.009
- Citations
- 1
- Primary Topic
- Diabetes Treatment and Management
- Type
- article
- Field-Weighted Citation Impact
- 1.29