Exploring the impact of NGS on diagnostics and treatment of sarcoma: insights from real-world data across multiple institutions in Europe
In conclusion, our data support the clinical utility of NGS fusion panels in diagnosing sarcomas in specific contexts. The therapeutic value of NGS remains limited, as reported before. However, given the overall paucity of molecular data for most sarcoma subtypes, we emphasize the importance of an international effort to collect molecular profiling of sarcomas to guide the design of clinical trials for specific targetable alterations.
Authors
- Katarzyna Seliga (ORCID: https://orcid.org/0000-0002-0358-3518)
- C. Serrano
- Claudia Valverde (ORCID: https://orcid.org/0000-0003-4107-8616)
- Ioannis Boukovinas (ORCID: https://orcid.org/0000-0003-4475-1802)
- Ramiro Álvarez (ORCID: https://orcid.org/0000-0002-8053-7232)
- Magdalena Rosińska (ORCID: https://orcid.org/0000-0002-6256-7809)
- Tania Silva (ORCID: https://orcid.org/0000-0003-2914-3120)
- Iwona Ługowska (ORCID: https://orcid.org/0000-0001-9511-178X)
- Anastasios Kyriazoglou (ORCID: https://orcid.org/0000-0003-3222-4060)
- Cleofé Romagosa (ORCID: https://orcid.org/0000-0002-9478-7320)
- Michał Wągrodzki (ORCID: https://orcid.org/0000-0001-5211-0736)
- Anna Malgorzata Czarnecka (ORCID: https://orcid.org/0000-0002-2107-3810)
- A Mala (ORCID: https://orcid.org/0009-0007-0555-524X)
- Stefania Kokkali
- M. Witczak
- Andrzej Tysarowski (ORCID: https://orcid.org/0000-0001-7726-490X)
- Asimina Koulouridi
- Agnieszka Zając (ORCID: https://orcid.org/0000-0001-8254-8229)
- P. Rutkowski
- Vassilis Georgoulias (ORCID: https://orcid.org/0000-0003-2218-2522)
- Piotr Błoński (ORCID: https://orcid.org/0009-0003-4289-7741)
- M Aguirre (ORCID: https://orcid.org/0000-0002-3852-338X)
Institutions
- Hospital General Universitario Gregorio Marañón (ES)
- The Maria Sklodowska-Curie National Research Institute of Oncology (PL)
- Polyclinic General Hospital (GR)
Publication Details
- Journal
- ESMO Open
- Published
- 2025-09-01
- DOI
- https://doi.org/10.1016/j.esmoop.2025.105577
- Primary Topic
- Sarcoma Diagnosis and Treatment
- Type
- article
- Field-Weighted Citation Impact
- 0.00