Combining computational target prioritization and a B cell maturation assay for target evaluation studies in systemic lupus erythematosus
Combining the target prioritization algorithm with experimental functional validation studies by gene knockdown and whole transcriptomics profiling constitutes a promising approach to identify potential novel drug targets in immune disorders.
Authors
- M. Sundström (ORCID: https://orcid.org/0009-0000-4972-5481)
- Hai Fang (ORCID: https://orcid.org/0000-0003-3961-8572)
- Ming-Mei Shang (ORCID: https://orcid.org/0000-0002-4480-6095)
- Sudeepta Kumar Panda (ORCID: https://orcid.org/0000-0001-7903-9255)
- Christine Möller Westerberg
- Julian Charles Knight (ORCID: https://orcid.org/0000-0002-0377-5536)
- Louise Berg (ORCID: https://orcid.org/0000-0001-6538-2837)
- Bogdan Knezevic (ORCID: https://orcid.org/0000-0002-2598-0629)
- Zhuang Liu (ORCID: https://orcid.org/0000-0001-8938-0086)
- Ning Xu (ORCID: https://orcid.org/0000-0003-4868-3798)
Institutions
- Karolinska University Hospital (SE)
- Centre for Human Genetics (GB)
- Ruijin Hospital (CN)
- Karolinska Institutet (SE)
- University of Oxford (GB)
Publication Details
- Journal
- Translational research
- Published
- 2025-09-01
- DOI
- https://doi.org/10.1016/j.trsl.2025.09.002
- Primary Topic
- Systemic Lupus Erythematosus Research
- Type
- article
- Field-Weighted Citation Impact
- 0.00