Innate and adaptive immune features associated with immune-related adverse events
A pre-existing activated, autoimmune-like proinflammatory state drives the development of irAE during ICI therapy through three key axes: increased plasmablast/ANA, heightened interferon-gamma/CXCL10/CXCR3 axis, and amplified TNF signaling. These findings may serve as potential peripheral immune biomarkers for predicting irAE and provide biological insights into the mechanisms governing and mitigating irAE.
Authors
- Hong Mu-Mosley
- Venkat S. Malladi (ORCID: https://orcid.org/0000-0002-0144-0564)
- Michelle Wu (ORCID: https://orcid.org/0000-0003-4541-8155)
- Farjana Fattah (ORCID: https://orcid.org/0000-0002-7897-2788)
- Edward K. Wakeland (ORCID: https://orcid.org/0000-0002-7107-0992)
- David J. Farrar (ORCID: https://orcid.org/0000-0001-8584-7080)
- Marjaan Imam
- Sheena Bhalla (ORCID: https://orcid.org/0000-0003-0614-9546)
- Yaming Xue
- Angela Moses (ORCID: https://orcid.org/0009-0009-3211-4356)
- David E. Gerber (ORCID: https://orcid.org/0000-0002-7812-6741)
- Angela B Mobley
- David Hsiehchen (ORCID: https://orcid.org/0000-0001-9139-302X)
- Jeffrey A. SoRelle (ORCID: https://orcid.org/0000-0003-2588-6277)
- Mitchell S. von Itzstein (ORCID: https://orcid.org/0000-0003-0530-3169)
- Quan‐Zhen Li (ORCID: https://orcid.org/0000-0002-7257-0489)
- Suzanne Cole (ORCID: https://orcid.org/0000-0001-8390-6315)
- Mary Gwin (ORCID: https://orcid.org/0009-0003-8627-7501)
- Yang Liu (ORCID: https://orcid.org/0000-0002-9442-700X)
- Tao Wang (ORCID: https://orcid.org/0000-0002-4355-149X)
- Jason Y. Park (ORCID: https://orcid.org/0000-0001-6797-4000)
- Yang Xie (ORCID: https://orcid.org/0000-0001-9456-1762)
- Shaheen Khan (ORCID: https://orcid.org/0000-0002-1472-8129)
- Jay Lohrey
Institutions
- Microsoft (United States) (US)
- National Institutes of Health (US)
- GeneCopoeia (United States) (US)
- University of Missouri–Kansas City (US)
- The University of Texas Southwestern Medical Center (US)
Publication Details
- Journal
- Journal for ImmunoTherapy of Cancer
- Published
- 2025-09-01
- DOI
- https://doi.org/10.1136/jitc-2025-012414
- Citations
- 8
- Primary Topic
- Cancer Immunotherapy and Biomarkers
- Type
- article
- Field-Weighted Citation Impact
- 8.36
Funders
- Society for Immunotherapy of Cancer