Perturbing neural stem cell fate in glioblastoma heterogeneity and beyond
Intratumoral heterogeneity in glioblastoma is thought to underlie its remarkable ability to recur and resist therapies. Its origins, however, remain unknown. In this issue, Liu et al. model the contributions of cell-of-origin and genetic drivers to intratumoral heterogeneity in glioblastoma, using a perturbation paradigm with broad neurodevelopmental applications.
Authors
- Ethan W. Hollingsworth (ORCID: https://orcid.org/0000-0002-5188-3929)
- Jaime Imitola
Institutions
- University of California, Irvine (US)
- University of California, Irvine Medical Center (US)
- UConn Health (US)
Publication Details
- Journal
- Stem Cell Reports
- Published
- 2025-09-01
- DOI
- https://doi.org/10.1016/j.stemcr.2025.102633
- Primary Topic
- Glioma Diagnosis and Treatment
- Type
- article
- Field-Weighted Citation Impact
- 0.00