Occurrence of dMMR/MSI-H tumor during follow-up in Lynch syndrome patients treated with immune checkpoint inhibitors for metastatic digestive cancer between 2015 and 2024: a retrospective analysis of a monocentric prospective cohort study
Our results show that patients with LS treated with ICIs for dMMR/MSI-H metastatic digestive cancers are at risk of developing metachronous dMMR/MSI-H cancers and preneoplastic colorectal polyps. This underlines the importance of dedicated long-term follow-up in this population, even after successful ICI treatment for their first digestive cancer.
Authors
- Anna Pellat (ORCID: https://orcid.org/0000-0001-6024-4830)
- Alexandre Perrier (ORCID: https://orcid.org/0000-0001-7607-6835)
- Jérémie H. Lefèvre (ORCID: https://orcid.org/0000-0001-7601-7464)
- Jacques Métras
- Romain Cohen (ORCID: https://orcid.org/0000-0001-9602-5162)
- Thomas Samaille (ORCID: https://orcid.org/0009-0006-4502-0058)
- Antoine Dardenne (ORCID: https://orcid.org/0009-0005-9059-7975)
- Yann R. Parc (ORCID: https://orcid.org/0000-0002-5631-3116)
- Thierry André (ORCID: https://orcid.org/0000-0002-5103-7095)
- C. Loisel
Institutions
- Délégation Paris 5 (FR)
- Inserm (FR)
- Université Paris Cité (FR)
- Sorbonne Université (FR)
- Institut National de Recherche pour l'Agriculture, l'Alimentation et l'Environnement (FR)
- Université Sorbonne Paris Nord (FR)
- Sorbonne Paris Cité (FR)
- Hôpital Cochin (FR)
- Assistance Publique – Hôpitaux de Paris (FR)
- Hôpital Saint-Antoine (FR)
- Pitié-Salpêtrière Hospital (FR)
- Hôpital Pontchaillou (FR)
- Centre de Recherche Saint-Antoine (FR)
- Centre de Recherche Épidémiologie et Statistique (FR)
Publication Details
- Journal
- ESMO Open
- Published
- 2025-09-01
- DOI
- https://doi.org/10.1016/j.esmoop.2025.105559
- Citations
- 5
- Primary Topic
- Genetic factors in colorectal cancer
- Type
- article
- Field-Weighted Citation Impact
- 7.36