Impact of DNA damage repair alterations on real-world response to therapy in metastatic colorectal cancer
In this real-world population, OS was improved in DDR-altered patients with metastatic colorectal cancer compared with DDR-wildtype patients. There was no difference in OS in DDR-mutated patients based on first-line treatment received.
Authors
- Ignacio Garrido‐Laguna (ORCID: https://orcid.org/0000-0003-2273-9028)
- Vaia Florou (ORCID: https://orcid.org/0000-0001-5558-753X)
- Laura Miotke
- Christine Norton (ORCID: https://orcid.org/0000-0003-2259-0948)
- Chris Nevala-Plagemann (ORCID: https://orcid.org/0000-0003-4048-2692)
- Zachary Rubnitz
Institutions
- Johns Hopkins University (US)
- University of Utah (US)
- Johns Hopkins Medicine (US)
- Huntsman Cancer Institute (US)
Publication Details
- Journal
- ESMO Open
- Published
- 2025-09-01
- DOI
- https://doi.org/10.1016/j.esmoop.2025.105768
- Primary Topic
- DNA Repair Mechanisms
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Institutes of Health