SAMHD1 promotes cardiac repair post myocardial infarction by targeting NR4a1 to regulate macrophage metabolic reprogramming
Our study revealed that macrophage-specific SAMHD1 deletion confers post-MI cardioprotection. More importantly, we demonstrated that NR4a1, a downstream target of SAMHD1, mediates the cardioprotective effects of SAMHD1 deficiency post-MI by regulating the remodeling of macrophage energy metabolism to promote the macrophage reparative phenotype.
Authors
- Chun‐Yan Kong (ORCID: https://orcid.org/0000-0002-6020-6452)
- Heyu Ni (ORCID: https://orcid.org/0000-0002-7621-2945)
- Yulan Ma
- Qizhu Tang (ORCID: https://orcid.org/0000-0003-2210-3169)
- Mingyu Wang (ORCID: https://orcid.org/0000-0002-8548-8783)
- Pan Wang (ORCID: https://orcid.org/0000-0002-9779-1878)
- Feng Guo (ORCID: https://orcid.org/0000-0001-5096-2142)
- Zhen Guo (ORCID: https://orcid.org/0000-0003-3967-4304)
- Yi-Peng Gao
Institutions
- Wuhan University (CN)
- Renmin Hospital of Wuhan University (CN)
Publication Details
- Journal
- Journal of Advanced Research
- Published
- 2025-09-01
- DOI
- https://doi.org/10.1016/j.jare.2025.09.018
- Citations
- 1
- Primary Topic
- Nuclear Receptors and Signaling
- Type
- article
- Field-Weighted Citation Impact
- 0.91