A preliminary investigation of the differences in immune responses in different strains of mice with localized allergic rhinitis tolerance models
Based on the criteria defining "local tolerance" in this model-significant symptom attenuation despite allergen escalation coupled with downregulation of nasal inflammatory markers (eotaxin, polymorphonuclear cell infiltration)-local tolerance was successfully induced in BALB/c mice by long-term OVA stimulation, but not in C57BL/6 mice. The normal function of T regulatory cells is key to establishing local tolerance.
Authors
- Zhixin Zou
- Qidi Zhang (ORCID: https://orcid.org/0000-0002-4918-597X)
- Wanting Zhu (ORCID: https://orcid.org/0000-0001-8692-3647)
- Ying Wang (ORCID: https://orcid.org/0000-0002-1407-2668)
- Jianjun Chen (ORCID: https://orcid.org/0000-0002-8631-4558)
- Pei Gao
- Ziyi Long
- Wenting Yu
Institutions
- Union Hospital (HK)
- Anhui Medical University (CN)
- First Affiliated Hospital of Anhui Medical University (CN)
- Huazhong University of Science and Technology (CN)
Publication Details
- Journal
- World Allergy Organization Journal
- Published
- 2025-09-01
- DOI
- https://doi.org/10.1016/j.waojou.2025.101115
- Primary Topic
- Allergic Rhinitis and Sensitization
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Natural Science Foundation of China