Analysis of genetic predisposition to familial non-medullary thyroid cancer by whole genome sequencing
Our data provide novel insight on the genetics of FNMTC. The P2RX5 p.Leu32Gln variant should be considered either as low-penetrant or not associated with PTC predisposition. MST1R appears as a new putative susceptibility gene for FNMTC that warrants further consideration.
Authors
- Rachel Desailloud (ORCID: https://orcid.org/0000-0001-9976-7938)
- Catherine Cardot-Bauters
- Emilie Ait‐Yahya (ORCID: https://orcid.org/0000-0002-7205-2649)
- Frédéric Frénois (ORCID: https://orcid.org/0000-0002-1405-0629)
- Julie Leclerc (ORCID: https://orcid.org/0000-0003-1130-7211)
- Emmanuelle Leteurtre (ORCID: https://orcid.org/0000-0002-2118-0704)
- Christine Do Cao (ORCID: https://orcid.org/0000-0002-1617-0149)
- F. Bonté
- Cathy Flament
- H. Topolinski
- Pascal Pigny (ORCID: https://orcid.org/0000-0003-3926-4487)
- Michel Crépin
Institutions
- Centre National de la Recherche Scientifique (FR)
- Inserm (FR)
- Université de Lille (FR)
- Centre Hospitalier Universitaire de Lille (FR)
- Centre Hospitalier Universitaire Amiens-Picardie (FR)
- Hôpital Albert Calmette (FR)
- Centre de Recherche en Informatique (FR)
- Centre Hospitalier de Béthune (FR)
- Onco Lille (FR)
- CANTHER - Hétérogénéité, Plasticité et Résistance aux Thérapies des Cancers (FR)
Publication Details
- Journal
- Annales d Endocrinologie
- Published
- 2025-09-01
- DOI
- https://doi.org/10.1016/j.ando.2025.102456
- Citations
- 1
- Primary Topic
- Thyroid Cancer Diagnosis and Treatment
- Type
- article
- Field-Weighted Citation Impact
- 1.29
Funders
- Centre hospitalier régional universitaire de Lille