Monocytes from people with Familial Hypercholesterolaemia are inflammatory, despite statin-treatment
Overall, monocytes show inflammatory skewing in FH individuals, even those with moderately-reduced cholesterol levels. These monocytes readily become inflammatory macrophages. This, along with subsequent inflammatory macrophage formation, could contribute to plaque destabilisation and downstream clinical events. This supports inflammatory monocyte targeting as a potential approach to reduce residual risk in FH individuals.
Authors
- Rana Baraz
- Helen Williams (ORCID: https://orcid.org/0000-0001-8221-5766)
- Habib Francis (ORCID: https://orcid.org/0009-0009-1106-4118)
- Rekha Marimuthu
- Stephen Li (ORCID: https://orcid.org/0000-0001-5010-771X)
- Heather J. Medbury (ORCID: https://orcid.org/0000-0002-1614-7213)
- Jian Huang (ORCID: https://orcid.org/0000-0001-6165-2182)
Institutions
- The University of Sydney (AU)
- Blacktown & Mount Druitt Hospital (AU)
- Westmead Hospital (AU)
Publication Details
- Journal
- Atherosclerosis Plus
- Published
- 2025-09-01
- DOI
- https://doi.org/10.1016/j.athplu.2025.09.002
- Primary Topic
- Lipoproteins and Cardiovascular Health
- Type
- article
- Field-Weighted Citation Impact
- 0.00