Concurrent idiopathic generalised tremor syndrome and bilateral trigeminal neuropathy in a dog ( <i>Canis lupus familiaris</i> )

Abstract A 3‐year‐old, neutered, male Labrador Retriever presented with a 1‐month history of bilateral temporal muscle atrophy, spontaneously resolving dropped jaw, and progressive generalised tremors. Neurological examination revealed opsoclonus, bilaterally incomplete menace response, increased muscle tone, subtle ambulatory tetraparesis, and reduced pelvic limb postural reactions. A multifocal neuro‐anatomical localisation involving the cerebellum, bilateral trigeminal nerves, C1–C5 and T3–L3 spinal cord segments was suspected. Magnetic resonance imaging showed mild bilateral trigeminal nerve thickening, cerebrospinal fluid analysis was normal, and screening for Neospora caninum and Toxoplasma gondii was negative. A 6‐month tapering course of prednisolone led to remission. Idiopathic generalised tremor syndrome was diagnosed based on characteristic clinical signs, negative diagnostic findings, and response to corticosteroids. The dropped jaw was attributed to idiopathic trigeminal neuropathy, supported by magnetic resonance imaging findings and spontaneous resolution. Generalised tremors recurred 13 months later, but resolved with the same treatment. This case describes a unique presentation of simultaneously occurring idiopathic generalised tremor syndrome and idiopathic trigeminal neuropathy.

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Publication Details

Journal
Veterinary Record Case Reports
Published
2025-09-09
DOI
https://doi.org/10.1002/vrc2.70199
Primary Topic
Neurological diseases and metabolism
Type
article
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article

Concurrent idiopathic generalised tremor syndrome and bilateral trigeminal neuropathy in a dog ( Canis lupus familiaris )

Charis Tang, Christoforos Posporis, E. Seidel, Alejandro Ororbia
3 links
Veterinary Record Case Reports
Neurological diseases and metabolism
article

Concurrent idiopathic generalised tremor syndrome and bilateral trigeminal neuropathy in a dog ( Canis lupus familiaris )

Charis Tang, Christoforos Posporis, E. Seidel, Alejandro Ororbia
article en

Abstract

Abstract A 3‐year‐old, neutered, male Labrador Retriever presented with a 1‐month history of bilateral temporal muscle atrophy, spontaneously resolving dropped jaw, and progressive generalised tremors. Neurological examination revealed opsoclonus, bilaterally incomplete menace response, increased muscle tone, subtle ambulatory tetraparesis, and reduced pelvic limb postural reactions. A multifocal neuro‐anatomical localisation involving the cerebellum, bilateral trigeminal nerves, C1–C5 and T3–L3 spinal cord segments was suspected. Magnetic resonance imaging showed mild bilateral trigeminal nerve thickening, cerebrospinal fluid analysis was normal, and screening for Neospora caninum and Toxoplasma gondii was negative. A 6‐month tapering course of prednisolone led to remission. Idiopathic generalised tremor syndrome was diagnosed based on characteristic clinical signs, negative diagnostic findings, and response to corticosteroids. The dropped jaw was attributed to idiopathic trigeminal neuropathy, supported by magnetic resonance imaging findings and spontaneous resolution. Generalised tremors recurred 13 months later, but resolved with the same treatment. This case describes a unique presentation of simultaneously occurring idiopathic generalised tremor syndrome and idiopathic trigeminal neuropathy.

Veterinary Record Case ReportsVol. 13(4)
Willows Veterinary Centre and Referral Service (GB), Southern Oncology Specialists (US)
Openalex Percentile: Top 70%
Neurological diseases and metabolism
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