Measuring alignment between the ADRC UDS data elements, FDA, and EHR data standards
Forty-five percent of Alzheimer's Disease Research Center Uniform Data Set (ADRC UDS) data elements could be mapped to Fast Healthcare Interoperability Resources (FHIR), indicating potential electronic health records (EHRs) extraction. Ninety-four percent of ADRC UDS data elements could be mapped to Clinical Data Interchange Standards Consortium (CDISC) Study Data Tabulation Model (SDTM), showing high industry compatibility. Identified areas for improving data standards harmonization in Alzheimer's disease and related dementias (ADRD) research. Systematic mapping method aligns ADRC UDS with Health Level Seven (HL7) FHIR and CDISC SDTM standards. Results support feasibility of data sharing across ADRC research, EHRs, and industry.
Authors
- Elizabeth C. LeRoy
- Amy E. Palmer (ORCID: https://orcid.org/0000-0002-5794-5983)
- Meredith Zozus (ORCID: https://orcid.org/0000-0002-9332-1684)
- Maryam Y. Garza (ORCID: https://orcid.org/0000-0002-2652-5935)
- Helen Foster (ORCID: https://orcid.org/0000-0001-8824-2546)
- Rhonda Facile (ORCID: https://orcid.org/0000-0002-6388-1795)
- Kayla Torres
- Z. Wang (ORCID: https://orcid.org/0009-0002-6748-6263)
- Melissa A. Kirwin
- Gary Walker
Institutions
- The University of Texas at San Antonio Health Science Center (US)
- Clinical Research Consortium (US)
Publication Details
- Journal
- Alzheimer s & Dementia
- Published
- 2025-09-01
- DOI
- https://doi.org/10.1002/alz.70628
- Citations
- 1
- Primary Topic
- Biomedical Text Mining and Ontologies
- Type
- article
- Field-Weighted Citation Impact
- 0.81