Enhancing immunotherapy efficacy in NSCLC through the combined use of phenelzine and <i>Akkermansia muciniphila</i> to regulate gut microbial metabolite 5-HIAA
Our investigations reveal that alterations in gut microbial composition leading to increased 5-HIAA synthesis can negatively impact CD8<sup>+</sup> T cell functionality and the success of immunotherapy. The combination of Phe and <i>AKK</i> supplementation holds potential for optimizing immunotherapy efficacy.
Authors
- Ke Chao
- Yuchao Ding
- Zhibo Shen
- Gautam Sethi (ORCID: https://orcid.org/0000-0002-8677-8475)
- Yahao Ge (ORCID: https://orcid.org/0000-0001-9691-5376)
- Yuanyuan Zheng (ORCID: https://orcid.org/0000-0002-7595-1375)
- Jie Zhao (ORCID: https://orcid.org/0000-0002-0776-9563)
- Kang Cui (ORCID: https://orcid.org/0000-0001-5534-3842)
- Yaqi Yang (ORCID: https://orcid.org/0000-0001-9460-6860)
- Yu Pu (ORCID: https://orcid.org/0009-0005-6428-1379)
- Lifeng Li (ORCID: https://orcid.org/0000-0002-7492-4017)
- Li Zhu (ORCID: https://orcid.org/0000-0001-5249-6536)
- Chun‐Wei Li (ORCID: https://orcid.org/0000-0002-9611-0858)
- Shilong Sun (ORCID: https://orcid.org/0000-0001-8034-9381)
- Yixing Zhang (ORCID: https://orcid.org/0000-0001-8780-4324)
- Yujie Wei
- Wenxuan Ji
- Yiqiong Song
- Longhao Wang (ORCID: https://orcid.org/0009-0008-9419-2010)
Institutions
- National University of Singapore (SG)
- Xinjiang Uygur Autonomous Region Uygur Medicine Hospital (CN)
- Henan Provincial People's Hospital (CN)
- First Affiliated Hospital of Zhengzhou University (CN)
- Xinjiang Uygur Autonomous Region Education Department (CN)
Publication Details
- Journal
- Journal for ImmunoTherapy of Cancer
- Published
- 2025-09-01
- DOI
- https://doi.org/10.1136/jitc-2025-011831
- Citations
- 3
- Primary Topic
- Gut microbiota and health
- Type
- article
- Field-Weighted Citation Impact
- 2.42
Funders
- National Natural Science Foundation of China
- Zhengzhou University
- Education Department of Henan Province
- First Affiliated Hospital of Zhengzhou University
- Wu Jieping Medical Foundation