Amyotrophic Lateral Sclerosis Masquerading as Multiple System Atrophy with Parkinsonism and Anxiety as Initial Manifestations

To our knowledge, this is the first case of ALS misdiagnosed as MSA. Clinically, patients with parkinsonism who do not respond to dopaminergic drugs should be cautious about atypical ALS. Muscle rigidity manifesting as upper motor neuron damage, and MR and <sup>18</sup>F-FDG brain PET imaging can provide early differential diagnosis indicators.

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Publication Details

Journal
Degenerative Neurological and Neuromuscular Disease
Published
2025-09-01
DOI
https://doi.org/10.2147/dnnd.s531647
Primary Topic
Parkinson's Disease Mechanisms and Treatments
Type
article
Field-Weighted Citation Impact
0.00
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article

Amyotrophic Lateral Sclerosis Masquerading as Multiple System Atrophy with Parkinsonism and Anxiety as Initial Manifestations

Jianping Yao, Haiyan Tang, Zhuang Wang
Degenerative Neurological and Neuromuscular Disease
Parkinson's Disease Mechanisms and Treatments
article

Amyotrophic Lateral Sclerosis Masquerading as Multiple System Atrophy with Parkinsonism and Anxiety as Initial Manifestations

Jianping Yao, Haiyan Tang, Zhuang Wang
article en

Abstract

To our knowledge, this is the first case of ALS misdiagnosed as MSA. Clinically, patients with parkinsonism who do not respond to dopaminergic drugs should be cautious about atypical ALS. Muscle rigidity manifesting as upper motor neuron damage, and MR and <sup>18</sup>F-FDG brain PET imaging can provide early differential diagnosis indicators.

Degenerative Neurological and Neuromuscular DiseaseVol. Volume 15
Huzhou Central Hospital (CN)
Openalex Percentile: Top 65%
Parkinson's Disease Mechanisms and Treatments
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