Upadacitinib Attenuates Lipopolysaccharide- and Cecal Ligation and Puncture-Induced Inflammatory Responses by Inhibiting NF-κB and Its Downstream Cytokines
Taken together, UPA inhibits the LPS- and CLP-induced inflammatory responses in vitro and in vivo, which is associated with the inhibition of NF-κB and its downstream cytokines.
Authors
- Xueting Yang (ORCID: https://orcid.org/0000-0003-4633-2185)
- Hongli Yan (ORCID: https://orcid.org/0000-0001-6366-0370)
- Qi Yao (ORCID: https://orcid.org/0000-0001-9905-1083)
- Ning Xu (ORCID: https://orcid.org/0000-0003-1186-6128)
- Yanlin Ma (ORCID: https://orcid.org/0000-0003-4782-3656)
- Yang Wang (ORCID: https://orcid.org/0000-0002-5040-2492)
Institutions
- Kunming University of Science and Technology (CN)
- First People's Hospital of Yunnan Province (CN)
- The First Hospital of Kunming (CN)
- Yunnan University of Traditional Chinese Medicine (CN)
Publication Details
- Journal
- Journal of Inflammation Research
- Published
- 2025-09-01
- DOI
- https://doi.org/10.2147/jir.s535747
- Primary Topic
- NF-κB Signaling Pathways
- Type
- article
- Field-Weighted Citation Impact
- 0.00