The Immunomodulatory Activity of Thymosin Alpha 1 on Tumor Cell Lines and Distinct Immune Cell Subsets
Our findings question the tumor immunomodulatory properties of Tα1, simultaneously underscoring the importance of further investigating Tα1 influence on specific immune cell subsets in the periphery or within the tumor microenvironment of cancer patients. This would contribute to understand Tα1 potential in immunotherapy-based combination strategies, within the anti-tumor setting.
Authors
- Michele Maio (ORCID: https://orcid.org/0000-0002-0323-6321)
- Anna Maria Di Giacomo (ORCID: https://orcid.org/0000-0001-9315-2158)
- Gianluca Giacobini
- Francesca Piazzini (ORCID: https://orcid.org/0009-0001-6371-6570)
- Fabrizio Celesti (ORCID: https://orcid.org/0000-0003-1629-0922)
- Maria Fortunata Lofiego (ORCID: https://orcid.org/0009-0009-4800-2084)
- Carolina Fazio
- Laura Solmonese (ORCID: https://orcid.org/0000-0003-3662-386X)
- Francesco Marzani (ORCID: https://orcid.org/0009-0005-9399-4511)
- Sandra Coral (ORCID: https://orcid.org/0000-0002-1308-3082)
- Alessia Covre
- Emma Bello (ORCID: https://orcid.org/0009-0006-3358-9327)
- Xiaohui Wang (ORCID: https://orcid.org/0009-0004-0884-8177)
Institutions
- University of Siena (IT)
- SciClone Pharmaceuticals (United States) (US)
- Epigenomics (Germany) (DE)
Publication Details
- Journal
- OncoTargets and Therapy
- Published
- 2025-09-01
- DOI
- https://doi.org/10.2147/ott.s527785
- Primary Topic
- Cellular Mechanics and Interactions
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Sanofi