SHLP2 alleviates allergic asthma by inhibiting ETV5/GSDMD signaling pathway-mediated pyroptosis
Overexpression of ETV5 improved mitochondrial function and reduced pyroptosis in bronchial epithelial cells. However, exogenous SHLP2 supplementation failed to reverse the exacerbation of HDM-induced lung inflammation and airway barrier damage caused by ETV5 knockout in mice. These findings highlight SHLP2 as a key ETV5/GSDMD signaling pathway regulator, inhibiting pyroptosis and mitigating AA progression.
Authors
- Shengpeng Li (ORCID: https://orcid.org/0009-0006-5018-4380)
- Chenhui Ma (ORCID: https://orcid.org/0000-0001-6254-1441)
- Xinhua Wang (ORCID: https://orcid.org/0000-0001-9458-2299)
- Yanli Zhang (ORCID: https://orcid.org/0000-0002-8942-5325)
- Wenlong Zhang (ORCID: https://orcid.org/0000-0002-2402-0685)
- Shuguang Han (ORCID: https://orcid.org/0000-0002-2893-6471)
- Yan Wang
Institutions
- Jiangnan University (CN)
Publication Details
- Journal
- Cellular Signalling
- Published
- 2025-09-10
- DOI
- https://doi.org/10.1016/j.cellsig.2025.112126
- Citations
- 1
- Primary Topic
- Inflammasome and immune disorders
- Type
- article
- Field-Weighted Citation Impact
- 0.81