Study of the role of interleukin-1β in blood serum in patients with acne

The topic of acne is not losing its relevance despite numerous studies performed in this field. Not only adolescents but also adults visit a dermatologist with this skin disease. Study of acne pathogenesis is of professional interest in order to develop new algorithms for diagnosis and treatment of dermatosis. Objective. To determine the level of interleukin-1β in the blood of patients with acne diagnosis and with acne occurring in presence of opisthorchiasis, and compare these indicators with those in the control group, as well as to identify the relationship between IL-1β and skin process severity in acne. Material and methods. The study included 235 female and male patients. Among them, 135 patients were diagnosed with acne with varying severity, other 100 patients were healthy donors without acne for comparison of IL-1β indicators. Results. Patients with acne and with acne in presence of chronic opisthorchiasis had IL-1β level of 2.50 (1.90; 3.20) pg/ml, which is significantly higher (p<0.001) than healthy donors — 0.30 (0.15; 0.18) pg/ml. A positive correlation between the severity of acne and the level of IL-1β has been also determined. The more severe the skin process in acne is, the higher the IL-1β level is (p<0.001). Conclusion. The obtained data on high IL-1β content in the blood serum in patients with acne and with acne in presence of chronic opisthorchiasis compared to healthy donors indicate maintenance of immune and inflammatory activity in the tissues of pilosebaceous follicle in patients with chronic dermatosis.