Investigation on Inhibiting SPHK - S1P Pathway to Improve ADHD Model Rats Behavior via Lipidomics
The SPHK-S1P signaling axis is a core pathway driving sphingolipid metabolic dysregulation in the prefrontal cortex in ADHD. Targeted inhibition of this pathway synergistically modulates the expression levels of proteins associated with dopaminergic neurotransmission. The limited regulatory effect of taVNS on sphingolipid metabolism suggests its clinical benefits may stem from multi-pathway synergistic mechanisms.
Authors
- Qianqian Cai (ORCID: https://orcid.org/0000-0002-0660-9963)
- Junxuan Lü (ORCID: https://orcid.org/0000-0002-2354-7186)
- Lihui Wu (ORCID: https://orcid.org/0000-0001-5606-524X)
- Yuhui Yao (ORCID: https://orcid.org/0009-0003-4988-2745)
- Chunyu Jiang (ORCID: https://orcid.org/0000-0002-4741-2286)
- Yin Sun (ORCID: https://orcid.org/0009-0000-8793-3169)
- Dingyue Chai
Institutions
- Jiading District Central Hospital (CN)
- Shanghai University of Medicine and Health Sciences (CN)
- First Hospital of Jiaxing (CN)
- Hangzhou Medical College (CN)
Publication Details
- Journal
- Neuropsychiatric Disease and Treatment
- Published
- 2025-09-01
- DOI
- https://doi.org/10.2147/ndt.s530564
- Primary Topic
- Tryptophan and brain disorders
- Type
- article
- Field-Weighted Citation Impact
- 0.00