CLEC5A Activation in Inflammatory Monocytes: A Mechanism for Enhanced Adaptive Immunity Following COVID-19 mRNA Vaccination in a Preclinical Study
These findings suggest that CLEC5A may play a role in bridging innate and adaptive immune responses during SARS-CoV-2 vaccination. Although further studies with different vaccine platforms are necessary to confirm and expand these observations, our results provide preliminary evidence supporting the potential of CLEC5A as an exploratory biomarker of vaccine-induced immunity.
Authors
- Juliana Gil Melgaço (ORCID: https://orcid.org/0000-0003-0087-6531)
- Luciana Tubarão (ORCID: https://orcid.org/0000-0001-7502-5593)
- Juliana Fernandes Amorim da Silva (ORCID: https://orcid.org/0000-0002-0673-6583)
- Raphaela Delmondes do Nascimento (ORCID: https://orcid.org/0000-0002-7570-5692)
- Carolina Baeta Salvador Várady (ORCID: https://orcid.org/0000-0003-3883-7714)
- J. R. De Medeiros (ORCID: https://orcid.org/0000-0001-8218-1586)
- Patrícia Neves (ORCID: https://orcid.org/0000-0002-5589-9354)
- Vanessa Pimenta Rocha
- Thiago Lazari Machado
- Andréa Marques Vieira da Silva (ORCID: https://orcid.org/0000-0003-4566-2545)
- Ana Paula Dinis Ano Bom (ORCID: https://orcid.org/0000-0002-2299-0792)
- Renata Tourinho Santos
- Tamiris Azamor (ORCID: https://orcid.org/0000-0002-4047-2091)
- Lorenna Carvalho da Rosa (ORCID: https://orcid.org/0000-0002-1236-523X)
- Felipe Soares Coelho
- Rodrigo Müller (ORCID: https://orcid.org/0000-0001-9877-7122)
- Jane Silva
- Renan Galuzo (ORCID: https://orcid.org/0009-0006-7182-9918)
Institutions
- UNSW Sydney (AU)
- Fundação Oswaldo Cruz (BR)
Publication Details
- Journal
- Viruses
- Published
- 2025-09-10
- DOI
- https://doi.org/10.3390/v17091233
- Citations
- 1
- Primary Topic
- SARS-CoV-2 and COVID-19 Research
- Type
- article
- Field-Weighted Citation Impact
- 1.40