Neurodegenerative Disease as A Potential Consequence of Aging in Cystic Fibrosis

New therapies in cystic fibrosis (CF) have made a significant impact on the overall health of people with CF (pwCF). Because of the success of these therapies, it is anticipated that lifespans of pwCF will significantly increase. For the first time, the impacts of aging with CF need to be considered. Until now, relatively little has been done to evaluate neurological health in pwCF. In this review, we consider evidence for a potential prevalence of neurodegenerative disease in CF including our recent study examining tauopathy in an aged CF mouse model.