Disease Outcomes in Immune-Mediated Colitis: A Study Describing Initial Endoscopic and Histologic Presentations and Treatment Options
Our study represents the largest to date exploring the various manifestations of IMC, along with associated treatment approaches and outcomes. We found that its features overlap with those of different inflammatory colitides. Both infliximab and vedolizumab were equally effective in achieving symptom remission; however, infliximab was associated with a shorter time to response. As the number of patients affected by IMC continues to grow, larger-scale studies will be essential to validate and expand upon these findings.
Authors
- Tanvi Gupta (ORCID: https://orcid.org/0000-0002-5443-5056)
- Douglas Buckner Johnson (ORCID: https://orcid.org/0000-0002-6390-773X)
- Hamza Adel Salim (ORCID: https://orcid.org/0000-0002-5208-8425)
- Carolina Colli Cruz (ORCID: https://orcid.org/0000-0001-7065-3769)
- Anusha Shirwaikar Thomas
- Kian Abdul-Baki
- Kei Takigawa (ORCID: https://orcid.org/0000-0001-9462-3193)
- Stéphane Champiat (ORCID: https://orcid.org/0000-0002-0741-2118)
- Linfeng Lu (ORCID: https://orcid.org/0000-0002-5703-5007)
- Karen Kim (ORCID: https://orcid.org/0000-0003-3466-5353)
- Malek Shatila (ORCID: https://orcid.org/0000-0001-8503-7811)
- Varun Vemulapalli
- Andrew Sullivan (ORCID: https://orcid.org/0000-0001-8556-0530)
- Ayesha Khan (ORCID: https://orcid.org/0009-0002-5531-6873)
- Elliot Baerman (ORCID: https://orcid.org/0000-0002-3750-7855)
- Cristina Natha
- Yinghong Wang (ORCID: https://orcid.org/0000-0002-5148-6130)
- Irene Lee (ORCID: https://orcid.org/0000-0003-0552-7429)
- Raakhi Menon
- Andres Caleb Urias Rivera
- Krishnavathana Varatharajalu
Institutions
- The University of Texas MD Anderson Cancer Center (US)
- Baylor College of Medicine (US)
- Vanderbilt University (US)
- Stanford Medicine (US)
- Memorial Hermann–Texas Medical Center (US)
- The University of Texas Health Science Center (US)
- The University of Texas Medical Branch at Galveston (US)
- The University of Texas Health Science Center at Houston (US)
Publication Details
- Journal
- Journal of the National Comprehensive Cancer Network
- Published
- 2025-09-01
- DOI
- https://doi.org/10.6004/jnccn.2025.7046
- Citations
- 1
- Primary Topic
- Microscopic Colitis
- Type
- article
- Field-Weighted Citation Impact
- 1.35