In Vitro and In Silico Analysis of Differential Antibacterial Activity of Pomegranate Polyphenols Against Gram-Positive and Gram-Negative Bacteria
Larger tannins exhibited strong target binding but limited porin permeability, reducing efficacy in Gram-negative bacteria. These findings provide insights into structure-activity relationships of pomegranate polyphenols and support their potential as natural antimicrobial agents.
Authors
- Ranko Škrbić (ORCID: https://orcid.org/0000-0002-6643-1781)
- Jelena Radović (ORCID: https://orcid.org/0000-0001-7324-1647)
- Maja Travar (ORCID: https://orcid.org/0000-0002-9599-1999)
- Relja Suručić (ORCID: https://orcid.org/0000-0003-1599-6210)
- Ljiljana Suručić (ORCID: https://orcid.org/0000-0003-4332-8690)
- Miloš P. Stojiljković (ORCID: https://orcid.org/0000-0001-9431-0736)
- Tatjana Kundaković Vasović
- Milan Momčilović (ORCID: https://orcid.org/0000-0001-5370-0148)
Institutions
- University of Nis (RS)
- University of Banja Luka (BA)
- Sechenov University (RU)
- University of Belgrade (RS)
Publication Details
- Journal
- Antibiotics
- Published
- 2025-09-10
- DOI
- https://doi.org/10.3390/antibiotics14090912
- Citations
- 1
- Primary Topic
- Pomegranate: compositions and health benefits
- Type
- article
- Field-Weighted Citation Impact
- 1.12