Case Report: Trilostane therapy in a dog with recurrent adrenocortical carcinoma producing an array of steroid hormones

This case highlights an initial clinical response to trilostane in a dog with metastatic, functional adrenocortical carcinoma (ACC), demonstrating short-term control of clinical signs. The variation in presentation between initial diagnosis and relapse prompted a hypothesis of a shift in tumor steroidogenic activity-a phenomenon rarely documented in veterinary literature. It underscores the diverse manifestations arising from excess production of multiple steroid hormones, including precursors. It also supports adrenal profiling in complex cases and confirms trilostane's utility as a palliative therapy in non-resectable or metastatic ACC.