Management and Outcomes of Multiple Unruptured Cerebral Aneurysms: A Descriptive Cohort Analysis

<b>Background:</b> Unruptured cerebral aneurysms pose a significant neurosurgical challenge due to their potential for rupture, which can lead to devastating subarachnoid hemorrhage. Advances in imaging have increased incidental detection of multiple unruptured aneurysms, necessitating tailored management strategies to balance rupture risk against treatment complications. <b>Methods:</b> We retrospectively analyzed 41 patients with 101 unruptured cerebral aneurysms, assessing demographics, aneurysm size and location, treatment modalities, and clinical outcomes. Descriptive statistics and correlation analyses examined associations between aneurysm characteristics, comorbidities, and post-treatment complications. <b>Results:</b> Most aneurysms were small (<10 mm, 48.5%), primarily located at the Middle Cerebral Artery Bifurcation (27.7%). Hypertension (56.1%) and smoking (53.7%) were prevalent risk factors. Clipping was the most common intervention (81.2%), with 41.4% of patients experiencing post-operative complications and 36.6% developing neurological deficits. <b>Conclusions:</b> This study underscores the difficulties in managing multiple unruptured cerebral aneurysms owing to diverse aneurysm characteristics and patient risk factors such as hypertension, hyperlipidaemia, and smoking. Clipping was the predominant intervention, with time customized for each individual case. Despite the occurrence of problems such as vasospasm and neurological difficulties, the majority of patients maintained functional independence. The results provide significant insights into the clinical attributes, therapeutic strategies, and outcomes for this patient cohort.

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Journal
Brain Sciences
Published
2025-09-10
DOI
https://doi.org/10.3390/brainsci15090973
Primary Topic
Intracranial Aneurysms: Treatment and Complications
Type
article
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article

Management and Outcomes of Multiple Unruptured Cerebral Aneurysms: A Descriptive Cohort Analysis

Oday Atallah, Amr Badary, Khadeja Alrefaie
Brain Sciences
Intracranial Aneurysms: Treatment and Complications
article

Management and Outcomes of Multiple Unruptured Cerebral Aneurysms: A Descriptive Cohort Analysis

Oday Atallah, Amr Badary, Khadeja Alrefaie
article en

Abstract

<b>Background:</b> Unruptured cerebral aneurysms pose a significant neurosurgical challenge due to their potential for rupture, which can lead to devastating subarachnoid hemorrhage. Advances in imaging have increased incidental detection of multiple unruptured aneurysms, necessitating tailored management strategies to balance rupture risk against treatment complications. <b>Methods:</b> We retrospectively analyzed 41 patients with 101 unruptured cerebral aneurysms, assessing demographics, aneurysm size and location, treatment modalities, and clinical outcomes. Descriptive statistics and correlation analyses examined associations between aneurysm characteristics, comorbidities, and post-treatment complications. <b>Results:</b> Most aneurysms were small (<10 mm, 48.5%), primarily located at the Middle Cerebral Artery Bifurcation (27.7%). Hypertension (56.1%) and smoking (53.7%) were prevalent risk factors. Clipping was the most common intervention (81.2%), with 41.4% of patients experiencing post-operative complications and 36.6% developing neurological deficits. <b>Conclusions:</b> This study underscores the difficulties in managing multiple unruptured cerebral aneurysms owing to diverse aneurysm characteristics and patient risk factors such as hypertension, hyperlipidaemia, and smoking. Clipping was the predominant intervention, with time customized for each individual case. Despite the occurrence of problems such as vasospasm and neurological difficulties, the majority of patients maintained functional independence. The results provide significant insights into the clinical attributes, therapeutic strategies, and outcomes for this patient cohort.

Brain SciencesVol. 15(9)
Carl von Ossietzky Universität Oldenburg (DE), Medizinische Hochschule Hannover (DE), Kuwait Institute for Medical Specialization (KW), Pius Hospital Oldenburg (DE), Evangelisches Krankenhaus Oldenburg (DE)
Openalex Percentile: Top 65%
Intracranial Aneurysms: Treatment and Complications
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