Increased tumor necrosis factor-receptor superfamily plasma levels are associated with early renal or retinal involvement in intermediate hyperglycemia
Our findings highlight the potential of TNF receptor superfamily members as biomarkers for early-stage renal and retinal complications in individuals with IH. Their integration into clinical screening protocols could facilitate earlier detection, improving patient stratification and personalized management strategies. Further longitudinal studies are necessary to validate their predictive value and potential for guiding therapeutic interventions in IH and early diabetes management.
Authors
- Esther Civantos (ORCID: https://orcid.org/0000-0002-9226-522X)
- Carmen Gómez‐Guerrero (ORCID: https://orcid.org/0000-0001-9001-5414)
- Marcus Lind (ORCID: https://orcid.org/0000-0002-3796-9283)
- Juan Antonio Moreno (ORCID: https://orcid.org/0000-0002-7468-2871)
- María Isabel López Gálvez (ORCID: https://orcid.org/0000-0002-7878-287X)
- Sebastián Mas (ORCID: https://orcid.org/0000-0001-6604-3327)
- Jaakko Tuomilehto (ORCID: https://orcid.org/0000-0002-3424-0745)
- Nisa Boukichou-Abdelkader (ORCID: https://orcid.org/0000-0002-7427-531X)
- Rafael Gabriel
- Jesús Egido (ORCID: https://orcid.org/0000-0001-6321-2666)
Institutions
- Universidad de Valladolid (ES)
- University of Helsinki (FI)
- Universidad de La Rioja (ES)
- Instituto de Salud Carlos III (ES)
- Centro de Investigación Biomédica en Red Diabetes y Enfermedades Metabólicas Asociadas (ES)
- Finland University (FI)
- 358 (Finland) (FI)
- Hospital Universitario Fundación Jiménez Díaz (ES)
- Universidad Alfonso X el Sabio (ES)
- University of Córdoba (ES)
- Universidad Autónoma de Madrid (ES)
- University of Gothenburg (SE)
Publication Details
- Journal
- World Journal of Diabetes
- Published
- 2025-09-10
- DOI
- https://doi.org/10.4239/wjd.v16.i9.106002
- Primary Topic
- Diabetes and associated disorders
- Type
- article
- Field-Weighted Citation Impact
- 0.00