Expression of IGF-1R in Skin Wound Healing Treated by Topical Application of Cinnamomum Zeylanicum

Objective: The aim of this study was to evaluate the immunohistochemical expression of IGF-1R on cutaneous wound healing. Material and Methods: A total of 18 male albino rats (Rattus norvegicus albinus) weighing nearly 300-400 gm were used in the present study. Two punch biopsies were done on the dorsum of each animal, and daily local application of cinnamon zeylanicum extract was performed on left side, while the right one was allowed to heal naturally (control measure). The process of wound skin healing was tracked for periods (1, 3, and 7 days), all specimens were processed for immunohistochemistry examination. Results: Based on immunohistochemical results, experimental groups had the highest mean values of IGF-1R expression in the stroma and epidermis when compared to control groups. These values increased with time, which was more noticeable on days three and seven of the experiments. Conclusion: Positive localization of IGFF-1R in rat's skin indicated the effectiveness of cinnamon zeylanicum extract in accelerating the healing process of cutaneous layers of skin.