Two-pronged immune evasion of pseudouridine-modified RNA
It is well established that pseudouridine (Ψ) and its derivative N<sup>1</sup>-methylpseudouridine (m<sup>1</sup>Ψ) suppress unwanted immunogenicity of RNA-based therapeutics. However, molecular mechanisms governing such immune evasion remain elusive. In a recent article, Bérouti, Wagner, and colleagues show that Ψ impairs the processing of Toll-like receptor (TLR)-agonistic ligands and hinders TLR activation.
Authors
- Jonas Cerneckis (ORCID: https://orcid.org/0000-0001-5778-2996)
- Yanhong Shi (ORCID: https://orcid.org/0000-0002-3938-5839)
Institutions
- City Of Hope National Medical Center (US)
- City of Hope (US)
Publication Details
- Journal
- Trends in Molecular Medicine
- Published
- 2025-09-10
- DOI
- https://doi.org/10.1016/j.molmed.2025.08.007
- Citations
- 1
- Primary Topic
- Virus-based gene therapy research
- Type
- article
- Field-Weighted Citation Impact
- 1.82