Accelerated long-term forgetting as a predictor of clinical onset in presymptomatic autosomal dominant Alzheimer’s disease
Severity of ALF is not only associated with the presence of AD pathology but also predictive of clinical onset, identifying those at the highest risk of imminent decline. ALF testing offers promise in aiding presymptomatic trial recruitment, as a presymptomatic cognitive endpoint and potentially as a screening tool in the wider population.
Authors
- Rachana Tank (ORCID: https://orcid.org/0000-0002-4771-6685)
- Helen Rice
- Philip S.J. Weston (ORCID: https://orcid.org/0000-0003-1033-9916)
- Kirsty Lu (ORCID: https://orcid.org/0000-0002-8416-2183)
- Nick C. Fox (ORCID: https://orcid.org/0000-0002-6660-657X)
- Antoinette O’Connor (ORCID: https://orcid.org/0000-0003-4467-128X)
- Sebastian J. Crutch (ORCID: https://orcid.org/0000-0002-4160-0139)
- Duncan Alston
- Nicholas Magill (ORCID: https://orcid.org/0000-0002-5138-3166)
- Damien Ferguson
Institutions
- London School of Hygiene & Tropical Medicine (GB)
- UK Dementia Research Institute (GB)
- National Hospital for Neurology and Neurosurgery (GB)
- University College London (GB)
Publication Details
- Journal
- Journal of Neurology Neurosurgery & Psychiatry
- Published
- 2025-09-09
- DOI
- https://doi.org/10.1136/jnnp-2025-336750
- Primary Topic
- Dementia and Cognitive Impairment Research
- Type
- article
- Field-Weighted Citation Impact
- 0.00