Hyper Immunoglobulin E Syndrome With Conjunctival Molluscum Contagiosum

We report a rare case of conjunctival molluscum contagiosum in a 4-year-old male with hyperimmunoglobulin E syndrome and disseminated molluscum contagiosum infection. The patient presented with bilateral periorbital and right conjunctival lesions, along with lesions on the face, neck, ears, trunk, back, and genitalia. He was being prepared for a bone marrow transplant, and surgical excision of the lesions was performed to reduce the viral load. Although this case demonstrates the atypical presentation of molluscum contagiosum in immunocompromised individuals, the conjunctival lesions have a unique presentation, which highlights the importance of considering underlying immunodeficiency in patients with unusual ocular manifestations of common viral infections.