Correlation of serum cytokine levels with disease severity in psoriasis: A physiological insight into inflammatory markers

Psoriasis is a chronic immune-mediated skin disorder in which systemic inflammation and cytokine dysregulation play central roles. Identifying correlations between cytokine levels and disease severity may aid in establishing reliable biomarkers. In this cross-sectional study, 60 psoriasis patients and 30 healthy controls were evaluated; PASI scores were recorded and serum TNF-α, IL-6 and IL-17 levels was measured using ELISA. All three cytokines were significantly elevated in patients and showed strong positive correlations with PASI scores. Elevated TNF-α, IL-6 and IL-17 may serve as biomarkers of disease activity and potential therapeutic targets in psoriasis management.