EXTRACTION AND ISOLATION OF BIOACTIVE COMPOUNDS FROM CORAL JUNCEELLA DELICATA (GRASSHOFF, 1999) FROM WEST COAST OF MUMBAI

Objective: To isolate the bioactive compounds from coral Junceella delicata (Grasshoff, 1999) collected from West coast of Mumbai. Methods: The coral J. delicata was collected from Patwadi Village, Madh Island, Malad West Mumbai-400061, Maharashtra, India, during the low tide. The sample was grinded with blender and then macerated by adding an equal volume of MeOH: DCM (1:1). The aliquot was concentrated in a rotary vacuum evaporator at 45 °C. The resultant compound was subjected to Millipore filter system and finally dried in vacuum desiccator. The sample was further subjected for TLC and pure compounds were processed for GC-MS and FTIR for structural determinations. Results: The distinct and well-separated compounds were processed for GC-MS and FTIR for their structural elucidation. These compounds are (Ethyl aminomethyl formimidate); (Gly-Gly); (2-(2-Pyridyl)-4 methylthiazole-5-carboxylic acid); (7-Methoxy-2-methylquinolin-4-ol); (Fraxidin); (2-methyl-3-trans-propenylpyrazine); (3-tert-Butylpyridine); (Acetaldehyde benzyl ethyl acetal); (α-Methylcinnamic acid); (4-Ethoxycoumarin); (3-Hydroxycoumarin); (2, 4, 7, 9-Tetramethyl-5-decyne-4, 7-diol); (2,2-Bis(3-allyl-4-hydroxyphenyl) propane); (Phenyltriethylammonium cation); (Dodecanedioic acid). These compounds showed biomedical properties. Conclusion: The isolated bioactive compounds may be used for pharmaceutical and therapeutic applications. Further studies, including molecular-level research, are necessary to confirm their mechanisms of action and clinical relevance. Additionally, safety and efficacy assessments are crucial to support the development of new pharmaceutical products aimed at improving human health.

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Publication Details

Journal
International Journal of Pharmacy and Pharmaceutical Sciences
Published
2025-09-01
DOI
https://doi.org/10.22159/ijpps.2025v17i9.54605
Citations
1
Primary Topic
Marine Sponges and Natural Products
Type
article
Field-Weighted Citation Impact
1.23

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article

EXTRACTION AND ISOLATION OF BIOACTIVE COMPOUNDS FROM CORAL JUNCEELLA DELICATA (GRASSHOFF, 1999) FROM WEST COAST OF MUMBAI

G. V. Zodape, Meenakshi Prakash Borate
1 citations
International Journal of Pharmacy and Pharmaceutical Sciences
Marine Sponges and Natural Products
1.23
article

EXTRACTION AND ISOLATION OF BIOACTIVE COMPOUNDS FROM CORAL JUNCEELLA DELICATA (GRASSHOFF, 1999) FROM WEST COAST OF MUMBAI

G. V. Zodape, Meenakshi Prakash Borate
article en
1 citations

Abstract

Objective: To isolate the bioactive compounds from coral Junceella delicata (Grasshoff, 1999) collected from West coast of Mumbai. Methods: The coral J. delicata was collected from Patwadi Village, Madh Island, Malad West Mumbai-400061, Maharashtra, India, during the low tide. The sample was grinded with blender and then macerated by adding an equal volume of MeOH: DCM (1:1). The aliquot was concentrated in a rotary vacuum evaporator at 45 °C. The resultant compound was subjected to Millipore filter system and finally dried in vacuum desiccator. The sample was further subjected for TLC and pure compounds were processed for GC-MS and FTIR for structural determinations. Results: The distinct and well-separated compounds were processed for GC-MS and FTIR for their structural elucidation. These compounds are (Ethyl aminomethyl formimidate); (Gly-Gly); (2-(2-Pyridyl)-4 methylthiazole-5-carboxylic acid); (7-Methoxy-2-methylquinolin-4-ol); (Fraxidin); (2-methyl-3-trans-propenylpyrazine); (3-tert-Butylpyridine); (Acetaldehyde benzyl ethyl acetal); (α-Methylcinnamic acid); (4-Ethoxycoumarin); (3-Hydroxycoumarin); (2, 4, 7, 9-Tetramethyl-5-decyne-4, 7-diol); (2,2-Bis(3-allyl-4-hydroxyphenyl) propane); (Phenyltriethylammonium cation); (Dodecanedioic acid). These compounds showed biomedical properties. Conclusion: The isolated bioactive compounds may be used for pharmaceutical and therapeutic applications. Further studies, including molecular-level research, are necessary to confirm their mechanisms of action and clinical relevance. Additionally, safety and efficacy assessments are crucial to support the development of new pharmaceutical products aimed at improving human health.

International Journal of Pharmacy and Pharmaceutical Sciences
G.S. Science, Arts And Commerce College (IN)
Indian Institute of Technology Madras, Indian Institute of Technology Bombay
Openalex Percentile: Top 18%
Marine Sponges and Natural Products
1.23
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