Baicalein improves motor dysfunction and cognitive impairment while promoting remyelination in an animal model of multiple sclerosis through the antioxidant mechanism
These data demonstrate that BA facilitates remyelination and development of OL lineage cells in the MS model of CPZ-exposed mouse by its antioxidant actions thereby encouraging future clinical applications of BA in treating patients with MS.
Authors
- Yanran Chen (ORCID: https://orcid.org/0000-0002-0475-2432)
- Haiyun Xu (ORCID: https://orcid.org/0000-0002-0752-6502)
- Qiongzhang Wang (ORCID: https://orcid.org/0000-0002-0140-9540)
- Bin Xu (ORCID: https://orcid.org/0000-0002-0499-0430)
- Yutong Li (ORCID: https://orcid.org/0000-0002-9085-9868)
- Qin Wang (ORCID: https://orcid.org/0000-0003-0672-9647)
- Ziwen Wang (ORCID: https://orcid.org/0000-0002-3724-1620)
Institutions
- Wenzhou University (CN)
- Wenzhou Medical University (CN)
- First Affiliated Hospital of Wenzhou Medical University (CN)
- Jinzhou Kangning Hospital (CN)
Publication Details
- Journal
- Frontiers in Pharmacology
- Published
- 2025-09-10
- DOI
- https://doi.org/10.3389/fphar.2025.1659631
- Primary Topic
- Neuroinflammation and Neurodegeneration Mechanisms
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Wenzhou Medical University
- National Natural Science Foundation of China