A rare case of mammary hamartoma presenting as malignant on radiological assessment and benign on pathological examination: a case report

Breast hamartomas are rare, benign, and encapsulated lesions composed of a combination of fatty, glandular, muscular, and fibrous tissue. Mammography provides an overview of the breast's structure and can identify the characteristic "breast within a breast" appearance typical of hamartomas. Ultrasound is useful for determining the echogenicity and vascularization of hamartomas, thereby helping to differentiate them from potential malignancies. Magnetic Resonance Imaging (MRI) is another indispensable tool in the diagnostic arsenal for breast hamartomas. One of the major challenges in differential diagnosis is distinguishing hamartomas from fibroadenomas, which typically occur in young women. Here, we present a case of a 21-year-old female with a highly suspicious lesion based on radiological features, which was ultimately diagnosed histologically as a breast hamartoma.

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Publication Details

Journal
Frontiers in Oncology
Published
2025-09-10
DOI
https://doi.org/10.3389/fonc.2025.1593952
Primary Topic
Breast Lesions and Carcinomas
Type
article
Field-Weighted Citation Impact
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article

A rare case of mammary hamartoma presenting as malignant on radiological assessment and benign on pathological examination: a case report

Jin Hua Hu, Qing‐Feng Yang, Yiping Gong
Frontiers in Oncology
Breast Lesions and Carcinomas
article

A rare case of mammary hamartoma presenting as malignant on radiological assessment and benign on pathological examination: a case report

Jin Hua Hu, Qing‐Feng Yang, Yiping Gong
article en

Abstract

Breast hamartomas are rare, benign, and encapsulated lesions composed of a combination of fatty, glandular, muscular, and fibrous tissue. Mammography provides an overview of the breast's structure and can identify the characteristic "breast within a breast" appearance typical of hamartomas. Ultrasound is useful for determining the echogenicity and vascularization of hamartomas, thereby helping to differentiate them from potential malignancies. Magnetic Resonance Imaging (MRI) is another indispensable tool in the diagnostic arsenal for breast hamartomas. One of the major challenges in differential diagnosis is distinguishing hamartomas from fibroadenomas, which typically occur in young women. Here, we present a case of a 21-year-old female with a highly suspicious lesion based on radiological features, which was ultimately diagnosed histologically as a breast hamartoma.

Frontiers in OncologyVol. 15
Wuhan University (CN), Renmin Hospital of Wuhan University (CN)
Openalex Percentile: Top 65%
Breast Lesions and Carcinomas
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A rare case of mammary hamartoma presenting as malignant on radiological assessment and benign on pathological examination: a case report — Jin Hua Hu, Qing‐Feng Yang, et al. · Frontiers in Oncology (2025) | TGRS Research Map | TGRS