Securinine, a novel alkaloid, regulates cell cycle and EMT in gastric cancer by inducing iron-dependent cell death
Securinine shows potential as a novel therapeutic agent for gastric cancer by inducing ferroptosis and modulating key cell death and survival pathways. Its ability to regulate iron metabolism and EMT suggests that it could be a promising candidate for developing new therapeutic strategies against gastric cancer, especially for drug-resistant cases.
Authors
- Xu Zhou (ORCID: https://orcid.org/0000-0003-2698-5357)
- Liang Song (ORCID: https://orcid.org/0000-0001-5236-5077)
- Zhangming Chen
- Yi Jiang (ORCID: https://orcid.org/0000-0002-7877-0561)
- Hao Song (ORCID: https://orcid.org/0000-0003-2197-1562)
- Jianye Han
- Yuehui Ji (ORCID: https://orcid.org/0000-0003-4815-4546)
- Shi Jiao (ORCID: https://orcid.org/0000-0003-3591-8973)
- Shi Yin (ORCID: https://orcid.org/0000-0001-5279-6926)
- Aman Xu (ORCID: https://orcid.org/0000-0002-6308-0488)
- Limin Liu (ORCID: https://orcid.org/0000-0002-4807-619X)
- Yuanmin Xu
- Weiwei Yuan (ORCID: https://orcid.org/0009-0004-2686-6918)
Institutions
- University of Science and Technology of China (CN)
- Nanjing University of Chinese Medicine (CN)
- Anhui Medical University (CN)
- Shanghai University of Traditional Chinese Medicine (CN)
- Maternity and Children's Hospital (SA)
- Wuhu No 1 People's Hospital (CN)
- Shanghai Traditional Chinese Medicine Hospital (CN)
- First Affiliated Hospital of Anhui Medical University (CN)
- Lu'an First People's Hospital (CN)
Publication Details
- Journal
- Frontiers in Oncology
- Published
- 2025-09-10
- DOI
- https://doi.org/10.3389/fonc.2025.1599680
- Primary Topic
- Ferroptosis and cancer prognosis
- Type
- article
- Field-Weighted Citation Impact
- 0.00