Transcriptome-based immune subtypes reveal the heterogeneity of tumor microenvironment in pediatric B-cell acute lymphocytic leukemia
Our study identified five immune subtypes that associated with distinct biological aberrations and clinical behaviors, which help us better understand the heterogeneity of TME and may provide valuable information for the precision therapy of pediatric B-ALL.
Authors
- Hongbin Meng (ORCID: https://orcid.org/0000-0002-8357-8603)
- Yueyue Fu (ORCID: https://orcid.org/0000-0002-5373-6367)
- Mingqiang Li (ORCID: https://orcid.org/0000-0002-5178-4138)
- Wenyi Hou
- Jinqiao Li (ORCID: https://orcid.org/0000-0002-0243-4174)
Institutions
- Harbin Medical University (CN)
- First Affiliated Hospital of Harbin Medical University (CN)
Publication Details
- Journal
- Frontiers in Oncology
- Published
- 2025-09-10
- DOI
- https://doi.org/10.3389/fonc.2025.1643160
- Primary Topic
- Acute Lymphoblastic Leukemia research
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Natural Science Foundation of China