Comparison of the pharmacokinetic profiles of three triterpenoids after oral administration of a cucurbitacin tablet and nanosuspension by UHPLC-MS/MS
The MP-NPs formulation significantly enhanced the oral bioavailability of cucurbitacin triterpenoids compared to conventional CUT. These findings underscore the potential of nanosuspension technology in improving the pharmacokinetic profile of cucurbitacin-based therapeutics. This study provides valuable insights for further development and clinical application of cucurbitacin nanosuspensions.
Authors
- Shuaijie Zhang
- C Wang
- Lihong Wu (ORCID: https://orcid.org/0000-0001-7657-3954)
- C. Zhang
- De-qiang Yang
- Zhibin Wang (ORCID: https://orcid.org/0000-0001-7441-7536)
- Ruitong Du
- Meng Wang (ORCID: https://orcid.org/0000-0002-7417-9192)
Institutions
- Harbin Medical University (CN)
- Heilongjiang University of Chinese Medicine (CN)
- Heilongjiang Provincial Hospital (CN)
Publication Details
- Journal
- Frontiers in Pharmacology
- Published
- 2025-09-10
- DOI
- https://doi.org/10.3389/fphar.2025.1647015
- Primary Topic
- Advances in Cucurbitaceae Research
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Heilongjiang University
- National Natural Science Foundation of China
- Natural Science Foundation of Heilongjiang Province
- Heilongjiang University of Chinese Medicine