Expression of inflammatory cytokines in CADASIL and their associations with clinical and neuroimaging features
Our results indicate that diffuse inflammatory pathway activation occurs in CADASIL. The increased expression level of TNF-β was associated with higher CMBs burden and poor clinical scores. Our findings suggest that the inflammatory pathway, particularly the TNF-related inflammatory pathway, may be involved in the disease progression of CADASIL.
Authors
- Qing Peng (ORCID: https://orcid.org/0000-0002-2238-8400)
- Tao Wu (ORCID: https://orcid.org/0000-0002-2400-6509)
- Wei Zhang (ORCID: https://orcid.org/0000-0001-8134-6908)
- Z. G. Wang
- Haiqiang Jin
- Yun Yuan (ORCID: https://orcid.org/0000-0003-3282-9123)
- Fan Li (ORCID: https://orcid.org/0000-0003-2584-3162)
- Zihao Zhang (ORCID: https://orcid.org/0000-0001-9286-8189)
- Ling Chen (ORCID: https://orcid.org/0000-0002-6909-9606)
- Zhaoxia Wang (ORCID: https://orcid.org/0000-0002-8723-4242)
- Yunchuang Sun
- Li Bai
- Hong-Jun Hao (ORCID: https://orcid.org/0000-0001-6434-9090)
- Haotian Yan
Institutions
- Peking University (CN)
- Institute of Biophysics (CN)
- Beijing Institute of Neurosurgery (CN)
- Beijing Anzhen Hospital (CN)
- Peking University First Hospital (CN)
- National Science Centre (PL)
- University of Chinese Academy of Sciences (CN)
Publication Details
- Journal
- Frontiers in Immunology
- Published
- 2025-09-10
- DOI
- https://doi.org/10.3389/fimmu.2025.1650847
- Primary Topic
- Cerebrovascular and genetic disorders
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Peking University First Hospital
- National Natural Science Foundation of China
- Chinese Academy of Sciences
- Peking University
- Institute of Biophysics, Chinese Academy of Sciences