Age is not a significant predictor of survival in patients with IDH-wildtype glioblastoma that undergo gross total resection and complete adjuvant chemoradiation
Age does not seem to be a factor in overall survival for glioblastoma when all the other prognostic factors are equalized. The idea that younger age is a positive prognostic factor is probably the result of more frequent IDH-mutant tumors in younger patients, increased incidence of frailty in older patients and the unwillingness of healthcare providers and patients/families to aggressively treat older patients.
Authors
- Hayan Dayoub
- John Gao (ORCID: https://orcid.org/0000-0002-8232-2024)
- C. Matthew Bradbury
- Breck A. Jones
- Kayla L. Chin
- Leslie Acakpo‐Satchivi
- Edem Agamah
- Krishna Rao (ORCID: https://orcid.org/0000-0002-1788-264X)
- Melissa Frankel
- Barbara C. Lokaitis
- Jeffrey W. Cozzens (ORCID: https://orcid.org/0000-0003-4576-6942)
- Kristin R. Delfino (ORCID: https://orcid.org/0000-0003-0075-1472)
- José A. Espinosa (ORCID: https://orcid.org/0000-0001-9674-8125)
- Devin V. Amin
- Noah B. Drewes
Institutions
- Southern Illinois University School of Medicine (US)
- Memorial Medical Center (US)
- Springfield Hospital (GB)
- Springfield Clinic (US)
Publication Details
- Journal
- Frontiers in Oncology
- Published
- 2025-09-10
- DOI
- https://doi.org/10.3389/fonc.2025.1657867
- Primary Topic
- Glioma Diagnosis and Treatment
- Type
- article
- Field-Weighted Citation Impact
- 0.00