Limited utility of faecal immunochemical testing in a colorectal cancer screening programme for adults with cystic fibrosis: insights from a prospective UK study
In this study, no cancer was detected in 76 consecutive eligible individuals who underwent colonoscopy. In 49 patients who had both FIT and colonoscopy, FIT did not aid colonic polyp detection, showing low sensitivity and no correlation between faecal haemoglobin and adenoma detection. Given the high adenoma prevalence, the limitations of FIT and the poor FIT return rate, colonoscopy should remain the preferred modality for CRC screening in pwCF.
Authors
- G. Horsman
- Anne-Marie Kelly
- Karuna Sapru (ORCID: https://orcid.org/0000-0001-8204-1452)
- Andrew M. Jones (ORCID: https://orcid.org/0000-0003-4114-1785)
- Javaid Iqbal (ORCID: https://orcid.org/0000-0001-6349-8887)
- Peter Barry (ORCID: https://orcid.org/0000-0001-6326-4431)
- Aqeem Azam (ORCID: https://orcid.org/0000-0001-9270-1127)
- Dipesh H. Vasant (ORCID: https://orcid.org/0000-0002-2329-0616)
- R.J. Bright-Thomas
Institutions
- University of Manchester (GB)
- Manchester University NHS Foundation Trust (GB)
Publication Details
- Journal
- BMJ Open Gastroenterology
- Published
- 2025-09-01
- DOI
- https://doi.org/10.1136/bmjgast-2025-001954
- Primary Topic
- Colorectal Cancer Screening and Detection
- Type
- article
- Field-Weighted Citation Impact
- 0.00