Diphenyl pyridine intervention improves S. aureus-induced pneumonia by globally regulating transcriptome profile
In summary, our study demonstrated that DP treatment can profoundly modulate the immune and inflammatory response by regulating the transcriptome profile of peripheral blood monocytes (PBMCs). The identified hub genes by DP treatment are potential therapeutic targets for <i>S. aureus</i>-induced pneumonia in future.
Authors
- Zhiwei Tian (ORCID: https://orcid.org/0000-0002-5139-6397)
- Qingfeng Zhu
- Hai Ci (ORCID: https://orcid.org/0000-0001-7170-277X)
- George Zhang (ORCID: https://orcid.org/0000-0003-2073-7109)
- Wei Duan (ORCID: https://orcid.org/0000-0002-4342-8184)
- Wanyu Li (ORCID: https://orcid.org/0000-0002-5684-5999)
- Zhengfu Yang (ORCID: https://orcid.org/0000-0003-2373-3701)
Institutions
- Shihezi University (CN)
- First Affiliated Hospital of Shihezi University Medical College (CN)
Publication Details
- Journal
- Frontiers in Genetics
- Published
- 2025-09-10
- DOI
- https://doi.org/10.3389/fgene.2025.1624327
- Primary Topic
- RNA modifications and cancer
- Type
- article
- Field-Weighted Citation Impact
- 0.00